NuMat Medtech is a biotechnology company located in the ParcBIT. Its main activity is the development of innovative biomaterials for bone anchored devices such as dental implants, orthopedic prostheses, scaffolds and bone filling devices for bone reconstruction and regeneration.
This way, the company intends to solve the main problems associated to this kind of implants, such as reduction of infections and inflammation, tissue regeneration around the implant, reduction of the risk of rejection and so on. .
The company was formed as a result of the merger between Sanifit Medtech and NuMat Biomedical. Sanifit Medtech was a spin-off from Laboratoris Sanifit, a leading company in the treatment of calcification disorders. NuMat Biomedical was created as a joint initiative of Numat AS (Norway) and Dr. Marta Monjo, Ph.D. In Molecular Biology with more than 10 years of experience in biomaterial research.
NuMat Biomedical and Sanifit Medtech started in 2013 a collaborative project called PHYTECH, designed to design and develop new bone implant materials. This project was funded with an INNPACTO project from the Ministry of Science and Innovation and a Eurostars project. Following the completion of the project, the two companies decided to join forces to take better advantage of the synergies between them and to create NuMat Medtech.
NuMat Medtech is developing a pipeline of products consisting of the bioactive treatment of multifunctional implant surfaces, addressed to solve the main problems related to the use of these implants: reduction of infections and inflammation, tissue regeneration around the implant, modulation of the osseointegrative properties and reduction of the risk of rejection.
Currently, the company is working on 4 main projects, all of them at the preclinical stage:
1) NM 971: Bioactive osteointegrative surface for compromised patients (e.g. osteoporotic or diabetic). It consists of a bioactive metal-containing and biocompatible surface coated with UV-activated 7-Dehydrocholesterol (7-DHC). The latter compund is a vitamin D precursor, so that once it is activated with UV-light, it stimulates the local production of the active vitamin in the implant area.
2) NM 973: Bioactive surface with osteogenic, osteoinductive, anti-inflammatory and anti-fibrotic properties. Reduces peri implantitis and implant failure risk. Metal surfaces functionalized with flavonoids, natural compounds from plants. Apart from its antioxidant activity, these bioactive compounds are well-known to have osteogenic, osteoinductive, anti-inflammatory and anti-fibrotic properties. It is of high interest to avoid peri-implantitis-occurrence.
3) NM 975: Slippery but osteopromotive surface for temporary implants. To be used in short-term implants, as splints, screws or bone plates, the surfaces used here are photo-activated with omega-3 polyunsaturated fatty acids (PUFA) combined with vitamins. Therefore, they promote bone healing while hindering tissue adherence to the implant surface.
4) NM 977: Bioactive surface modified with phytate for improving bone integration and decreasing bacterial adhesion. Metallic surfaces covered with phytate, another plant compound that inhibits bone resorption and bacterial adhesion.
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